INDIANAPOLIS -- It was just Peyton Mannings luck. Brent Grimes Jersey . On his first trip back to Lucas Oil Stadium, he and his teammates had an off night. His successor and his old team, they got it right. Andrew Luck threw three touchdown passes and ran for another score Sunday night, handing Denver a 39-33 loss -- its first of the season -- without even needing one of Lucks trademark fourth-quarter comebacks. "Its not real fun watching him," Luck said of Manning. "But he is something to watch." Heading into the game, Manning and Denver (6-1) looked virtually unbeatable. The Broncos were scoring points by the dozens in the midst of a 17-game regular-season winning streak and showed no signs of even hitting a speed bump. Then came what was supposed to be Mannings happy homecoming. Nothing went right and now the Kansas City Chiefs are the NFLs lone unbeaten team. He lost a fumble, threw an interception and was sacked four times -- twice by Robert Mathis, one of the few remaining holdovers from the Manning era. Broncos kick returner Trindon Holliday fumbled twice, losing one that led to a Colts touchdown. Denvers defence committed inexplicable penalties throughout the second half, giving the Colts more opportunities than they needed, and the Broncos last good chance fizzled when Denver running back Ronnie Hillman lost a fumble inside the Colts 5-yard line with 3:03 left in the game. With Luck and the Colts repeatedly taking advantage, even Manning couldnt rescue the Broncos. While Manning finished with solid numbers, 29 of 49 for 386 yards with three TD passes, he certainly wasnt himself. Passes fluttered, passes sailed, passes were broken up. Luck was 21 of 38 for 228 yards with three scores and no turnovers in ending Denvers pursuit of perfection. Indianapolis (5-2) extended its lead in the AFC South and still hasnt lost consecutive games since Luck arrived in the NFL last year. "This is a game we need to learn from. We, I guess, had four turnovers and still somehow had a chance to win that game," Manning said. "I would have liked to have seen it go to a two-point game down there toward the end and see what would have happened, but it never quite got to that point. You can go back to different parts of the game and we got behind, mistakes there, but we still had a chance there at the end. We certainly have to improve from this game because we werent as sharp execution-wise as wed like to be." Admittedly, this was no typical night for Manning. The weekends marquee matchup was the NFLs most anticipated homecoming since Brett Favre went back to Green Bay -- with the dreaded Minnesota Vikings -- in 2009. Indys former franchise quarterback dealt with questions all week about owner Jim Irsays most recent comments expressing disappointment with winning just one Super Bowl title during the Manning years, then arrived to find out the roof and window at Lucas Oil Stadium would be open on a chilly night inside the house he helped build. And when he first ran onto the field, some sections in the lower bowl looked like a checkerboard of Colts blue and Broncos orange. They roared for No. 18 throughout a 90-second video tribute featuring some of his most memorable moments with the Colts including the record-breaking pass to Marvin Harrison for most TDs by a quarterback-receiver duo, the AFC championship comeback against New England and, of course, the evening when he finally hoisted the Lombardi Trophy in rainy Miami. Manning responded to the standing ovation by stopping his warm-up throws, taking off his helmet, waving to the fans and mouthing the words "Thank you." The large video screen then cut to a fan holding a sign that that read "Thanks Peyton But Tonight Im A Colts Fan." Afterward, he acknowledged it was an emotional game. But the Broncos were dealing with far bigger issues on the field. After Holliday fumbled, Luck hooked up with Darrius Heyward-Bey on the next play to give Indy a 10-7 lead. Mathis second-quarter strip sack forced a safety and Luck found Stanley Havili for a 20-yard TD pass after the free kick to make it 19-14. Indy never trailed again. "Thats my job, thats how I help my team," Mathis said. "It felt good." The Colts extended the lead to 26-14 at halftime and 33-14 in the third quarter when Luck scrambled for a 10-yard TD during a drive on which four flags came out on Denver defenders. Then Manning rallied the Broncos, throwing a 31-yard TD pass to Demaryius Thomas early in the fourth and handing off to Knowshon Moreno for a 1-yard TD run to make it 36-30 with 8:44 left in the game. Denver forced a punt, giving Manning another chance as the stadium noise subsided. But on the first play, Erik Walden hit Mannings arm and Pat Angerer picked it off to set up Adam Vinatieris 42-yard field goal. "Hopefully well have a chance to play these guys again because that would mean we made the playoffs," Manning said. "I think if there is a next time it may be a little bit easier just because it was somewhat of an emotional week and it can be a little bit draining, I will say that." NOTES: The game could prove costly for both teams. Denver cornerback Champ Bailey left in the second quarter with a left foot injury, the same foot that kept him out of the first five games this season. Indy lost Pro Bowl receiver Reggie Wayne in the fourth quarter with what team officials called a sprained right knee. Wayne is expected to have an MRI on Monday. ... Colts cornerback Vontae Davis mistakenly referred to Manning as Tom Brady during a postgame interview on NBC. ... Denver rushed 20 times for 64 yards. Evan Smith Jersey . -- Jack Del Rio only wanted to talk about the Cowboys, not the Trojans. Authentic Tampa Bay Buccaneers Jerseys . While coach Doc Rivers high-fived fans and pumped his fist at the crowd, Blake Griffin and Chris Paul quietly congratulated each other. http://www.cheapbuccaneersjerseyssale.com/?tag=john-lynch-jersey-sale . Grilli hasnt pitched since straining his left oblique in late April. Manager Clint Hurdle says the right-hander will make a couple of appearances in middle relief before the team determines whether to return Grilli to the back end of the bullpen.EAST RUTHERFORD, N.J. -- Despite the sudden retirement of running back David Wilson, the New York Giants are confident that they have enough depth at the position. The 23-year-old Wilson announced his retirement on Monday because of neck and back injuries. "I feel for him," said quarterback Eli Manning, whose brother Cooper had his football career end because of a similar injury at the University of Mississippi. And his other older brother, Peyton, overcame spinal fusion surgery two years ago. "Its a tough situation, but it could have been a lot worse. Its a little bit scary, but he made the right decision by walking away. Were all going to miss him, because he was going to be a big part of our offence." And one Giants player, in particular, could relate to Wilsons situation. Linebacker Jameel McClain, signed as a free agent from Baltimore in the off-season, suffered a similar injury to the one that ended Wilsons career when McClain was with the Ravens in 2012. McClain suffered a bruised spinal cord and aggravated a long-standing case of spinal stenosis. At the time, McClain was told by Ravens doctors that he would never play football ever again. After the injury, McClain was released by the Ravens and signed by the Giants. He is listed on the depth chart as their starting middle linebacker, with projected starter Jon Beason still recovering from a broken foot suffered in minicamp in June. "I can understand to a certain extent," McClain said. "I can relate because of the circumstances and having the same options. I really didnt know much about my injury. The situation is a little different, but I had the same numbness and tingling my neck, hands and feet. After I first came here and we met each other, I talked to David and told him about my situation." McClain said that he was born with a slight case of spinal stenosis. "What happened to David felt so real to me," said McClain, who started 10 games for the Ravens last season before getting hurt, and had 52 tackles and a forced fumble. "I was told that I would never play again," he said. "David is a young man with a lot of talent. Its a wild situation how this happened." McClain did not have surgery to correct his problem. "I spent three months, had a test, waited another three months, had another test," McClain said. "I dont know if it was toughness or ignorance, but I didnt know much about it to be scared. I had to confront my situation and have been moving in the right direction." McClain has not had to endure another burner or stinger as Wilson had last Tuesday. M.J. Stewart Jersey. . "Sometimes, you have to put your future in the hands of nature and God," McClain said. "Playing again was something I just needed to do in time. I was focused on coming right back. I havent had another stinger in a long while and I dont plan on having another." Still, McClain feels bad for Wilson. "My thoughts and prayers are with him 100 per cent," McClain said. Several of Wilsons teammates expressed confidence that the team has depth at the position. "He always came out with a smile on his face," running back Peyton Hillis said. "The whole week, weve been like that. We still think we have a strong running back group. We have a group of guys who can produce. We have power backs who can get yardage when we need it. But make no bones about it. David Wilson will be missed." Coach Tom Coughlin started the teams early morning meeting on Tuesday by talking about Wilson. "He said, Once a Giant, always a Giant," Coughlin said. "He didnt want pity and I think that was a key. I related my feelings about David and his attitude. He actually helped me to understand it all better." Coughlin said that he had his concerns about Wilson, especially having the spinal fusion surgery last January. "There was always the possibility that he couldnt return," Coughlin said. "We were very concerned and very aware." But the Giants moved on without the former first-round pick. "Our running backs all did a good job," Coughlin said about the teams rushing attack in a 17-13 win against Buffalo in the Hall of Fame game on Sunday night. Rookie Andre Williams was the most impressive of the Giants rushers. The fourth-round pick from Boston College gained 48 yards on seven carries and had a touchdown against Buffalo. "Im not surprised at all," Coughlin said of Williams performance. "Its what we expected. Thats why we drafted him." NOTES: The Giants held their first night practice of training camp, practicing from 5:30 p.m. to 7:30 p.m. Some of those on the injured list who missed the preseason game, such as OT Will Beatty and DE Robert Ayers, returned to practice Tuesday. ... The Giants face the Pittsburgh Steelers in their second preseason game at home Saturday night. ... The Giants signed defensive end Israel Idonije, who played nine years for the Chicago Bears and last season for the Detroit Lions, and tight end Jerome Cunningham, who will be in his first professional camp. ... RB Peyton Hillis left practice with a sprained ankle. 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